Zinc Finger Protein 460 (ZNF460)

Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins.The partial ZNF272 cDNA, which lacks 5-prime coding sequence, encodes 4 functional C-terminal zinc finger domains followed by 1 degenerate finger motif. Northern blot analysis detected a major 7.0-kb ZNF272 transcript in HeLa cells, U-937 cells, and PMA-induced U-937 cells, with higher expression in the monocyte/macrophage lineages.The deduced 562-amino acid protein has a calculated molecular mass of 64 kD. ZNF272 contains a double KRAB domain at the N terminus and 11 C2H2-type zinc finger motifs at the C terminus, suggesting a role in DNA binding.