Zinc Finger Protein 497 (ZNF497)

Zinc finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. As a member of the Krüppel C2H2-type zinc finger protein family, ZNF497 is a 498 amino acid protein containing fourteen C2H2-type zinc fingers. Localized to the nucleus, ZNF497 is thought to be involved in transcriptional regulation. The gene encoding ZNF497 localizes to chromosome 19, which is recognized for having the greatest gene density of the human chromosomes. Chromosome 19 is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc receptors (FcRs). Key genes for eye color and hair color also map to chromosome 19.