Zinc Finger Protein 558 (ZNF558)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain.  They have also found use in protein engineering due to their modularity and have prospects as components of tools for use in therapeutic gene modulation and zinc finger nucleases.Zinc finger protein 558 (ZNF558) is a 402 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZNF558 contains nine C2H2-type zinc fingers and one KRAB domain through which it is thought to be involved in DNAbinding and transcriptional regulation.