Zinc Finger Protein 674 (ZNF674)

ZNF674 encodes a zinc finger protein with an N-terminal Kruppel-associated box-containing (KRAB) domain and 11 Kruppel-type C2H2 zinc finger domains. Like other zinc finger proteins, this gene may function as a transcription factor. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked mental retardation. Alternative splicing results in multiple transcript variants encoding different isoforms.The ZNF674 cDNA encodes a protein with KRAB A and B domains and 11 Kruppel-type C2H2 zinc finger domains. The transcript of ZNF674 has an open reading frame of 1,743 basepairs, with start and stop codons at positions 212 and 1955 of the cDNA, respectively. PCR of cDNA showed expression of ZNF674 in fetal brain, Epstein-Barr virus-immortalized B lymphocyte cell lines (EBV-LCLs), and testis.