Zinc Finger Protein 687 (ZNF687)

By sequencing clones obtained from a size-fractionated adult brain cDNA library, Nagase et al. (2000) cloned ZNF687, which they designated KIAA1441. The cDNA contains repetitive elements in its 5-prime end. The deduced 1,258-amino acid protein contains C2H2-type zinc finger domains, suggesting it has a role in nucleic acid management. RT-PCR ELISA detected ZNF687 in all adult and fetal tissues examined except spleen. Among specific brain regions examined, highest expression was found in amygdala, corpus callosum, cerebellum, caudate nucleus, and spinal cord.In a case of acute myeloid leukemia, Nguyen et al. (2006) identified ZNF687 as a novel translocation partner gene of RUNX1. In silico data and the cytologic location of the break in the reciprocal translocation indicated that the ZNF687 gene is located at 1q21.2.