Zinc Finger Protein 70 (ZNF70)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain.By hybridization to a panel of somatic cell hybrids containing various deletions of chromosome 22, Aubry et al. (1992) mapped the genes encoding 2 zinc finger proteins to the short arm of chromosome 22 and 4 others to the 22q11.2 region. Hitherto, the short arms of acrocentric chromosomes were thought to encode only ribosomal RNA genes. The genes assigned to 22p were ZNF72 and ZNF73; those assigned to 22q11.2 were ZNF69, ZNF70, ZNF71, and ZNF74.