Zinc Finger Protein 720 (ZNF720)

ZNF619, Contains 1 KRAB domain.Despite its name, it does not contain a canonical C2H2-type zinc-finger.The Krüppel associated box (KRAB) domain is a category of transcriptional repression domains present in approximately 200 human zinc finger protein-based transcription factors. The KRAB domain typically consists of about 75 amino acid residues whilst the minimal repression module is approximately 45 amino acid residues. It is predicted to function through protein-protein interactions via two amphipathic helices. Substitutions for the conserved residues abolish repression.The KRAB domain has been found in association with the C2H2-Zinc finger proteins and is confined to mammalian genomes. The KRAB containing C2H2-ZNF genes constitute the largest sub-family of zinc finger genes. More than half of the C2H2-ZNF genes are associated with a KRAB domain in the human genome.