Zinc Finger Protein 74 (ZNF74)

By hybridization to a panel of somatic cell hybrids containing various deletions of chromosome 22, Aubry et al. (1992) mapped the genes encoding 2 zinc finger proteins to the short arm of chromosome 22 and 4 others to the 22q11.2 region.  Aubry et al. (1993) found that the ZNF74 gene was hemizygously deleted in 23 out of 24 DiGeorge syndrome patients tested. ZNF74 mRNA transcripts were detected in human and mouse embryos but not in adult tissues. Sequence analysis of a corresponding cDNA demonstrated an open reading frame encoding 12 zinc finger motifs of the Kruppel/TFIIIA type, as well as N-terminal and C-terminal non-zinc finger domains. Changes in dosage of this putative transcription factor occurring with deletion of ZNF74 may be involved in DiGeorge developmental anomalies.