Zinc Finger Protein 75D (ZNF75D)

ZNF75D encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75 family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another functional gene belonging to this family is located on chromosome 16, while pseudogenes have been identified on chromosomes 11 and 12. Alternative splicing results in multiple transcripts variants.The deduced 289-amino acid protein contains a 42-amino acid Kruppel-associated box (KRAB-B) encoded by exon 2 and 5 zinc finger motifs in tandem encoded by exon 3.ZNF75A and 2 pseudogenes, ZNF75B and ZNF75C. They identified homologs in great apes and confirmed that the ZNF75 family is highly conserved through evolution.