Zinc Finger Protein 79 (ZNF79)

By analysis of its segregation pattern in a rodent/human hybrid panel, Huebner et al. (1993) mapped the ZNF79 gene to 9q34, centromeric to the ABL gene.The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Alterations of ABL1 by chromosomal rearrangement or viral transduction lead to malignant transformation, as in chronic myeloid leukemia (CML).The nuclear ABL tyrosine kinase can enhance transcription, and this activity is inhibited by RB. Thus, nuclear ABL is an S phase-activated tyrosine kinase that might participate directly in the regulation of transcription.