Zinc Finger Protein 8 (ZNF8)

Zinc finger protein 8 is a protein encoded by the ZNF8 gene.The zinc finger DNA-binding motif is found in a variety of transcriptional regulatory proteins. By screening a placenta library with the zinc finger-encoding region of the HF10 (ZNF35) cDNA, Lania et al. (1990) isolated a ZNF7  cDNA and a partial ZNF8 cDNA. The predicted ZNF8 protein contains 7 zinc finger domains. Northern blot analysis revealed that ZNF8 is expressed as 2.2- and 11-kb mRNAs in various human cell lines. By in situ hybridization, Lania et al. (1990) mapped the ZNF8 gene to 20q13.A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA.