Zinc Finger Protein 804A (ZNF804A)

Using a yeast 2-hybrid system to screen cDNA expression libraries, including an adult brain cDNA library, Lim et al. (2006) showed that C2ORF10 bound N-terminal sequences of ataxin-1 (ATXN1) containing either 30 or 82 glutamine repeats.Hartz (2008) mapped the ZNF804A gene to chromosome 2q32.1 based on an alignment of the ZNF804A sequence with the genomic sequence (build 36.1).ATXN1 gene spans 450 kb of genomic DNA and is organized into 9 exons. The first 7 fall in the 5-prime untranslated region, whereas the last 2 contain the coding region and a 7,277 bp 3-prime untranslated region. The first 4 noncoding exons undergo alternative splicing in several tissues.