Zinc Finger Protein 83 (ZNF83)

Marine et al. (1994) assigned the ZNF83 gene (also known as HPF1) to chromosome 19 by screening a human/rodent hybrid panel and localized the gene further to 19q13.3-q13.4 by fluorescence in situ hybridization and digital imaging microscopy. Conserved structural motifs define large families of nucleic acid binding proteins in eukaryotes. The C2H2-type zinc finger motif, conferring both specific RNA and DNA binding activities, was first detected within the amino acid sequence of the Xenopus transcription factor IIIA. Thereafter, vertebrate genomes were shown to encode hundreds of so-called zinc finger proteins (ZFPs). Subfamilies were defined on the basis of conserved sequence elements outside the finger repeat, such as the KRAB domain. Several members of these subfamilies were found to have a clustered genomic organization.