Zinc Finger Protein 830 (ZNF830)

CCDC16 is a 372 amino acid protein that belongs to the C2H2-type zinc finger family of proteins. Localizing to the nucleus, CCDC16 contains one U1-type zinc finger motif and is involved in premRNA splicing. CCDC16 functions as a component of a pre-mRNA splicing complex of the spliceosome, PRP19, CCDC16, HCNP, ISY1 and Cyclophilin E) and is required for proper RNA synthesis in the cell. Pre-mRNA splicing is essential to remove internal non-coding regions of pre-mRNA (introns) and to join the remaining segments (exons) into mRNA before translation. In preimplantation embryos, CCDC16 is believed to play an important role in cell cycle regulation. Further supporting its vital role in embryos, the disruption of CCDC16 leads to early embryonic lethality. Upon DNA damage, CCDC16 is phosphorylated by ATM or ATR.