Zinc Finger Protein 85 (ZNF85)

Members of the Kruppel zinc finger protein subfamily, which function as transcriptional regulators, are characterized by repeated zinc finger motifs that are connected by conserved H/C link regions.The predicted ZNF85 protein has a small N-terminal nonfinger region followed by a C-terminal domain containing 15 tandemly repeated zinc finger motifs.The deduced 595-amino acid protein, which contains at least 1 nuclear localization signal in its ZNF91-related spacer region, localizes to the nucleus. ZNF85 binds to DNA in a zinc-dependent manner.ZNF85 KRAB domain exhibits transcriptional repression activity and specifically interacts with several nuclear factors. RNase protection assays demonstrated that ZNF85 is expressed preferentially in testicular tissues.