Zinc Finger Protein 90 Homolog (ZFP90)

The predominant cDNA encodes a protein with a calculated molecular mass of 72.4 kD. The N-terminal half of Zfp90 contains KRAB A and B domains, and the C-terminal half contains 13 C2H2-type zinc finger motifs. Northern blot analysis detected a 2.4-kb transcript expressed at highest levels in brain, heart, spleen, and thymus. RT-PCR of mouse embryos detected Zfp90 expression predominantly in brain. At about postnatal week 2, it was expressed in most other tissues tested. At postnatal days 18 to 20, it was detected in testicular tissue, simultaneous with the appearance of haploid cells.The deduced protein shares 50% identity with ZNF471 and 85% identity with Halobacterium transcription initiation factor IIB5. RT-PCR ELISA detected intermediate to high expression in all adult and fetal tissues and specific brain regions examined.