Zinc Finger RNA Binding Protein 2 (ZFR2)

ZFR2 Contains 1 DZF domain. shuffling of C2H2 ZFs from dimerization zinc-finger (DZF) domains found in the human Ikaros and other related transcription factors can yield synthetic multifinger domains with novel protein–protein interaction specificities. n addition, a finger shuffling strategy could provide a means to create a repertoire of different protein–protein interaction pairs. Such a collection of synthetic C2H2 ZF protein–protein interaction domains together with existing collections of designer C2H2 ZF DBDs would constitute a useful toolbox of parts for creating or modifying transcription and signaling networks in cells.DZFs consist of two C2H2 ZFs joined by a short linker and have been identified in members of the mammalian Ikaros family of transcription factors as well as in the D. melanogaster Hunchback protein and the mammalian TRPS-1 protein.