Zinc Finger, SWIM-Type Containing Protein 2 (ZSWIM2)

ZSWIM2, Contains 2 RING-type zinc fingers.Contains 1 SWIM-type zinc finger.Contains 1 ZZ-type zinc finger. E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymesZSWIM2 is expressed at low level, only 16.6% of the average gene in this release.The gene contains 10 different gt-ag introns. Transcription produces 4 different mRNAs, 3 alternatively spliced variants and 1 unspliced form. There are 2 probable alternative promotors, 3 non overlapping alternative last exons and 3 validated alternative polyadenylation sites. The mRNAs appear to differ by truncation of the 5""" end, truncation of the 3""" end.