Zinc Finger, SWIM-Type Containing Protein 6 (ZSWIM6)

Zswim5 expression in the forebrain was found drastically decreased comparing to embryonic stages. On the contrary, Zswim6 was found persistently expressed in the mature forebrain, including striatum, cortex, hippocampus, and olfactory bulb. Among these brain regions, Zswim6 was relatively down-regulated in the cortex after P14. In addition, distinct neuronal progenitor populations express Zswim5 or Zswim6. Based on the results of double in situ hybridization/immunohistochemistry of Zswim5 and Zswim6 with the differentiation marker Tuj1 or the proliferation marker KI67, both Zswim5 and Zswim6 were likely to express in the differentiating but not the proliferating progenitors. Zswim5 was characterized with some MGE markers that specify different progenitor populations, such as Nkx2.1, Lhx6, and Lhx8.