Zinc Finger, X-Linked Duplicated Protein A (ZXDA)

ZXDA is the telomeric copy; GeneID 158586 ZXDB is the more centromeric copy. The two genes have 98% nucleotide sequence similarity, and the predicted proteins contain 10 tandem zinc finger motifs.A comparison between 1.2 kb of ZXDA coding sequence, which is contained within a single exon, and the corresponding sequence of ZXDB revealed 98.7% nucleotide sequence identity. Southern blot analysis detected sequences homologous to the ZXDA and ZXDB genes in a number of placental mammalian species. These data suggested that the ZXDA and ZXDB genes arose from a very ancient and highly conserved gene duplication. The predicted partial ZXDA and ZXDB proteins contain 10 tandem zinc finger motifs. Northern blot analysis showed approximately 6.5-kb ZXDA and ZXDB transcripts.