Zymogen Granule Protein 16 (ZG16)

ZG16, Belongs to the jacalin lectin family. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane and aggregated secretory proteins during granule formation in the TGN. Jacalin is a plant based lectin, however not a legume lectin, found in jackfruit. It has been studied for capturing O-glycoproteins such as mucins and IgA1, for potential applications in human immunology.Jacalin belongs to the family of galactose-binding lectins and it has a tetrameric two-chain structure with a weight of 66 kDa. Jacalin is preferably used in applications to isolate IgA from human serum, isolating human plasma glycoproteins and for applications in histochemistry. The lectin is blood group non-specific after neuraminidase treatment and agglutinates human erythrocytes at a concentration of ≥ 7,8 µg/ml.