rRNA Methyltransferase 2, Mitochondrial (MRM2)
Английские синонимы
FJH1; FTSJ2; Cell Division Protein FtsJ; 16S rRNA [Um1369] 2"""-O-methyltransferase; 16S rRNA (uridine(1369)-2"""-O)-methyltransferase
The deduced 246-amino acid protein has a calculated molecular mass of 27.4 kD and contains a methyltransferase domain. An iterative search of all available DNA sequences suggested that FTSJ2 is a member of a large and diverse family of evolutionarily conserved S-adenosylmethionine-binding proteins from bacteria to human, which contains at least 180 members.Northern blot analysis detected a 1.7-kb transcript in most tissues, with highest expression in muscle, placenta, and heart. A 2.6-kb transcript, which may represent a splice variant, was detected in heart. Both transcripts were found in all cancer cells tested. Ching et al. (2002) localized fluorescence-tagged FTSJ2 to the nucleolus of transiently transfected HeLa cells.
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
