Chemokine Like Factor Superfamily 7 (CKLFSF7)

Members of the chemokine-like factor superfamily, including CKLFSF7, share similarity with both the chemokine and the transmembrane 4 superfamilies of signaling molecules.By screening databases for sequences that share homology with chemokine-like factor (CKLF), followed by RT-PCR of a placenta cDNA library, Han et al. (2003) cloned CKLFSF7. They also detected a splice variant. The deduced 175-amino acid protein contains 4 transmembrane domains. Northern blot analysis detected a major 1.37-kb transcript that was highly expressed in leukocytes. Han et al. (2003) also cloned mouse Cklfsf7, which shares almost 89% sequence similarity with CKLFSF7.