Interferon Alpha Inducible Protein 27 (IFI27)

Rasmussen et al. (1993) isolated a new cDNA, which they called p27, from estradiol-treated human breast carcinoma cells. It encoded a putative highly hydrophobic protein of 122 amino acids that had a 33% overall sequence similarity to the product of the interferon-induced protein IFI-6-16 (IFI616). The latter gene is transcriptionally induced by interferons of the alpha and beta type.Rasmussen et al. (1993) mapped the IFI27 gene to 14q32 by isotopic in situ hybridization. They showed that it also is induced by interferon-alpha in human cell lines of different origin and that expression is independent of the presence of estradiol receptor in the cells.