Interferon Induced Protein With Tetratricopeptide Repeats 2 (IFIT2)

In addition to their role in the defense against microbial infections, interferons (IFNs) exhibit antiproliferative and differentiating activities that may confer on them potential as antitumor agents. Exposure to IFNs leads to a modulation in the levels of many cellular proteins that mediate the pleiotropic effects of interferons. These effects may be mediated by soluble factors or by cell-cell interactions involving specific membrane proteins.Using cloned probes on Southern blots of DNA from a panel of rodent-human somatic cell hybrids, Wathelet et al. (1988) assigned the IFI54K gene to chromosome 10. Thus it is syntenic with the IFI56K gene (147690). By in situ hybridization, Lafage et al. (1992) concluded that both the IFI54K and the IFI56K genes are located in the 10q23-q24 region.