Interleukin 4 Induced Protein 1 (IL4I1)

IL4I1 shares the limited similarity with L-amino acid oxidase, and contains the conserved key amino acid residues thought to be involved in catalysis and binding of the flavin adenine dinucleotide cofactor.The expression of this gene can be induced by interleukin 4 in B cells. The predicted 567-amino acid protein has a calculated molecular mass of 63 kD. It contains an N-terminal signal peptide, a central region that shares homology with nonmammalian LAAOs, and 3 conserved domains likely to be involved in FAD binding. The C terminus of human IL4I1 is 63 residues shorter than that of the mouse protein. IL4I1 was preferentially expressed in primary mediastinal large B-cell lymphomas rather than nonmediastinal diffuse large B-cell lymphomas.