Myeloid Derived Growth Factor (MYDGF)

The deduced 173-amino acid protein contains 2 O-glycosylation sites and several potential phosphorylation sites. There was evidence of 2 additional splice variants. The human and mouse C19ORF10 proteins share 91% sequence identity. Immunohistochemistry analyses of recombinant C19ORF10 in cultured FLSs and in synovial tissue sections from patients with rheumatoid arthritis (RA) or osteoarthritis (OA) revealed intracellular staining consistent with localization in the endoplasmic reticulum/Golgi apparatus. Sections of RA and OA synovia expressed similar patterns of C19ORF10 distribution with perivascular and synovial lining staining. Double-staining in situ analysis suggested that fibroblast-like synovial cells produced C19ORF10, whereas macrophages, B cells, or T cells produced little or none of this protein.