PDGFA Associated Protein 1 (PDAP1)

By screening a retina cDNA library with rat PAP sequence as probe, Fischer and Schubert (1996) cloned the human homolog, designated PDAP1, encoding a deduced 181-amino acid protein. The authors found no obvious secretion signal peptide. Northern blot analysis of newborn rat tissues detected expression in all tissues tested except liver; abundant expression was found in brain.Fischer and Schubert (1996) found that PDAP1 enhanced PDGFA (173430)-stimulated cell growth in mouse fibroblasts, but inhibited the mitogenic effect of PDGFB (190040). It had no effect on the action of any other growth hormone tested. Solid-phase binding studies showed that the binding between PDGFA and PDAP1 is a low affinity/high capacity interaction.