Transmembrane Emp24 Protein Transport Domain Containing Protein 1 (TMED1)

TMED1 encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1). This protein lacks any similarity to other interleukin 1 ligands. The functional significance of its interaction with IL1RL1 is not known.Sequence analysis predicted that the 227-amino acid, type I transmembrane protein, which lacks any similarity to any of the IL1 types, contains a 170-amino acid extracellular region between the signal peptide and the transmembrane domain as well as a 12-amino acid cytoplasmic tail. Northern blot analysis detected wide expression of a 1.5-kb transcript. Functional analysis failed to show that the interaction of IL1RL1LG and IL1RL1 leads to the activation of DNA binding by nuclear factor kappa-B (NFKB) or transcription from the IL8 promoter.