Sorting Nexin 1 (SNX1)

SNX1 is a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members. The major difference between SNX1 and SNX1A is a deletion of 195 nucleotides that results in an in-frame deletion of 65 amino acids; thus, SNX1A cDNA is predicted to encode a 457-amino acid hydrophilic protein. By PCR, the authors confirmed the presence of both SNX1 and SNX1A mRNAs in multiple tissues.