G Protein Coupled Receptor 173 (GPR173)

SREB3 contains several features of the GPCR family, including 7 transmembrane domains, potential N-linked glycosylation sites in the N-terminal extracellular domain, and conserved cysteine residues, which may form a disulfide bridge, in the first and second extracellular loops. However, SREB3 shares additional characteristics with SREB1 and SREB2 that are not also shared with other GPCRs, including identical amino acid substitutions of residues conserved in other GPCRs, an absence of prolines in the fifth transmembrane domain, and a relatively large conserved third cytoplasmic loop that has no sequence similarity to the third cytoplasmic loops of other GPCRs.Within brain, SREB3 expression was found in all regions tested, with the highest levels in the cerebellum and cerebral cortex.