Renin Binding Protein (RENBP)

Renin-binding protein, originally isolated from porcine kidney, is a proteinaceous renin inhibitor. In inhibiting renin, the protein forms a complex with it, so-called high molecular weight renin. The nucleotide sequences of cDNAs encoding the porcine, human, and rat renin-binding proteins, the predicted amino acid sequences consist of 402, 417, and 419 amino acids, respectively. Sequences of the three are highly homologous. The leucine zipper motif, which is a key structure for the formation of a heterodimer or a homodimer of several proteins, was also conserved in each RENBP. it spans about 10 kb and consists of 11 exons separated by 10 introns. By polymerase chain reaction amplification of hybrid DNAs from human and hamster somatic cells, they demonstrated that the RENBP gene is located on the X chromosome.