Acid Phosphatase 6, Lysophosphatidic (ACP6)

Lysophosphatidic acid phosphatase type 6 is an enzyme encoded by the ACP6 gene.Two initiation codons were identified, resulting in proteins of 428 and 421 amino acids, respectively, and the authors reported that the second ATG was the initiation codon in ACP6. The protein has a signal sequence and an N-terminal consensus sequence shared by a group of acid phosphatases, and it shares 28.5% amino acid identity with ACPP. Northern blot analysis detected a 1.75-kb transcript in all tissues examined with higher expression in kidney, heart, small intestine, muscle, and liver. They showed that ACP6 was localized to mitochondria by signal peptides and regulated the biosynthesis of mitochondrial lipids by hydrolyzing lysophosphatidic acid (LPA) to monoacylglycerol.