Adenylate Cyclase 1, Brain (ADCY1)

Adenylate cyclase type 1 is a form of adenylate cyclase expressed in brain. A similar protein in mouse is involved in pattern formation of the brain.The neural-specific, calmodulin-sensitive adenylyl cyclase (type I), which was first cloned from bovine brain, has been implicated in learning and memory.Villacres et al. (1993) cloned the gene for human fetal brain type I adenylyl cyclase. By database analysis and PCR of human embryonic kidney cell cDNA, Ludwig and Seuwen (2002) cloned full-length ADCY1. The deduced protein contains 1,119 amino acids. Semiquantitative RT-PCR detected ADCY1 highly expressed in peripheral blood leukocytes. Moderate or low ADCY1 levels were detected in brain and most other tissues examined except thymus, prostate, and small intestine.