Adenylate Cyclase 4 (ADCY4)

Adenylate cyclase type 4 is a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. By database analysis and PCR of a human trabecular bone cell cDNA library, Ludwig and Seuwen (2002) identified full-length ADCY4. The deduced protein contains 1,077 amino acids. Semiquantitative RT-PCR detected ubiquitous expression of ADCY at moderate levels.