FK506 Binding Protein 7 (FKBP7)

FK506 Binding Protein 7 belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. A similar protein in mouse is located in the endoplasmic reticulum and binds calcium.The deduced 218-amino acid protein contains an N-terminal hydrophobic signal sequence, a PPIase motif, 2 EF-hand domains, and 2 putative N-glycosylation sites. The calculated molecular mass is about 25 kD, but becomes 33 kD following cleavage of the signal sequence. Northern blot analysis detected expression of a 0.9-kb transcript predominantly in heart, lung, and testis. Immunolocalization in transfected COS-7 cells revealed a perinuclear distribution that overlapped that of an endoplasmic reticulum resident protein.