Hyaluronan Binding Protein 1 (HABP1)

HABP1 is translocated to the nucleus upon mitogenic stimulation.Hyaluronic Acid (HA), also called hyaluronate or hyaluronan, is a mucopolysaccharide widely distributed throughout the body. HA is produced mainly by fibroblasts and other specialized connective tissue cells.HABP is hyaluronic acid binding protein. Detection of 34 kDa HABP in the serum-free supernatant culture medium of fibroblasts was further evident by immunoblot analysis, thus confirming the secretory nature of HABP and its occurrence in the extracellular matrix.HABP binding to C32 cells and erythrocytes was independent of peptide charge or peptide structure. HABP efficiently prevented the basic fibroblast growth factor/epidermal growth factor (bFGF/EGF)-dependent proliferation of human umbilical vein endothelial cells.