Signaling Lymphocytic Activation Molecule Family, Member 6 (SLAMF6)

SLAMF6 is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs).The deduced 332-amino acid type I transmembrane NTBA protein is a member of the immunoglobulin superfamily. It has a leader peptide; 7 potential N-linked glycosylation sites in its 204-residue extracellular region; a transmembrane region lacking charged residues; and an 83-amino acid intracytoplasmic portion containing 2 TxYxxV/I motifs, which are thought to interact with SH2D1A, and an immunoreceptor tyrosine-based inhibitory motif (ITIM).