Cytochrome P450 1B1 (CYP1B1)

CYP1B1 a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.CYP1A1 and CYP1B1 are regulated by the Aryl hydrocarbon receptor, a ligand activated transcription factor. They are part of the Phase I reactions in drug metabolism.