Glutathione S Transferase Kappa 1 (GSTk1)

Pemble et al. stated that rat GST 13-13 was originally purified from mitochondria. Based on this localization and on its unique sequence, they proposed that rat GST 13-13 constitutes a novel family of GSTs that they termed kappa. Pemble et al. cloned the cDNA encoding rat GST 13-13, which they renamed GSTK1. They assembled a human cDNA sequence from sequences in EST databases. The deduced 225-amino acid human GSTK1 polypeptide is 70% identical to rat GSTK1. Pemble et al. noted that the GSTK1 sequence contains a putative peroxisomal targeting sequence.Morel et al. determined that the GSTK1 gene contains 8 exons and spans 5.68 kb. Exon 8 encompasses the 3-prime UTR. The promoter region contains no CCAAT or TATA boxes, but it has binding sites for STAT and SP1 transcription factors and a GC-rich region.