Histone Cluster 1, H1c (HIST1H1C)

HIST1H1C is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.histone H1.2 was a cytochrome c-releasing factor that appeared in the cytoplasm after exposure of cells to x-ray irradiation. While all nuclear histone H1 forms were released into the cytoplasm in a p53 (TP53)-dependent manner after irradiation, only H1.2 induced cytochrome c release from isolated mitochondria in a BAK (BAK1)-dependent manner. Reducing H1.2 expression enhanced cellular resistance to apoptosis induced by x-ray irradiation or etoposide, but not that induced by other apoptotic stimuli.