Lectin Like Oxidized Low Density Lipoprotein Receptor 1 (LOX1)

Oxidized low-density lipoprotein receptor 1 is a protein that in humans is encoded by the OLR1 gene. This gene encodes a receptor protein which belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein.This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer"""s disease. Alternative transcript variants have been described but their full-length sequence has not been determined. Berberine inhibits ORL1 (LOX-1)with the improvement in hemoglobin A1c and AGEs in diabetics.