Cell Division Cycle Protein 5 Like Protein (CDC5L)

CDC5L shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.The putative 802-amino acid protein is significantly homologous to the S. pombe Cdc5 gene product and contains 2 tandem repeats of a helix-turn-helix DNA-binding motif with similarity to Myb-related proteins, 4 consensus nuclear localization signals, a proline-rich, hydrophobic region similar to known activation domains, and 28 potential sites for phosphorylation by intracellular kinases.