Jun B Proto Oncogene (JUNB)

A second EPO-independent peak of JUNB expression was associated with erythroid cell differentiation as measured by increased expression of erythroid-specific proteins.More than 50% of the JUNB locus is contained in these flanking evolutionarily conserved sequences (FECSs), which may be required for effecting the proper transcriptional regulation of the gene. Comparative sequence analyses involving kilobases of distal flanking DNAs for only a small number of vertebrate genes suggested that FECSs may emerge as common yet important functional components of genes. If they account for a large fraction of the conserved sequence within a disease-related locus, then deleterious mutations might frequently occur in these regions and go undetected with current strategies