V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog (ARAF)

This sequence, which they called PKS (presumably for """protein kinase sequence"""), showed 71% nucleotide homology to RAF1. The predicted amino acid sequence of the kinase domain was sufficiently like the sequence of v-raf to suggest that PKS may encode a polypeptide with serine/threonine kinase activity.Mark et al. (1986) found that expression of PKS mRNA (2.7 kb) was elevated in peripheral blood mononuclear cells isolated from 2 patients with angioimmunoblastic lymphadenopathy with dysproteinemia, a disease in which autoantibodies are produced following the lymphoproliferative activation of B cells.As an initial step in the analysis of this RAF1-related cDNA, they isolated a human ARAF cDNA and used it to map the genes in mouse and man.