Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 1 (HCN1)

Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain. The mouse and human genes display unique patterns of mRNA expression in different tissues, including brain and heart. Both BCNG1 and BCNG2 contain the conserved motifs of a voltage-gated potassium channel, including the S1-S6 transmembrane segments, a charged S4 voltage-sensor, and a pore-lining P loop. In addition, both contain a conserved CNBD in their respective carboxy termini. The 308-amino acid core region of the human BCNG1 protein, extending from the S1 through the S6 transmembrane segments, is 100% identical to that of mouse Bcng1. The main site of expression of BCNG1 is brain.