Nucleoporin 85kDa (NUP85)

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160.By proteomic analysis and mass spectrometry, Cronshaw et al. (2002) identified 94 proteins associated with NPCs purified from rat liver nuclei. Database analysis identified FLJ12549, which Cronshaw et al. (2002) called NUP75, as the human homolog of a rat protein found in relative abundance, with 16 copies per NPC. The deduced human protein has a calculated molecular mass of 75 kD and is homologous to the yeast Nup85 protein.