Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1)

UHRF1 encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase II alpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.The protein has a calculated molecular mass of about 90 kD. ICBP90 contains an N-terminal ubiquitin-like domain partially overlapped by a leucine zipper domain, followed by a central zinc finger of the PHD finger type and a C-terminal zinc finger of the ring finger type.