Carbonic Anhydrase VII (CA7)

Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.Montgomery et al. mapped the partially characterized CA7 isozyme to chromosome 16q21-q23 by analysis of somatic cell hybrids and by in situ hybridization. The mRNA for CA VII was detected only in salivary glands.