Glycogen Synthase Kinase 3 Alpha (GSK3a)

Glycogen synthase kinase 3 is a serine/threonine protein kinase, that mediates the addition of phosphate molecules on certain serine and threonine amino acids in particular cellular substrates. The phosphorylation of these other proteins by GSK-3 usually inhibits the target protein.As mentioned, GSK-3 is known for phosphorylating and thus inactivating glycogen synthase.Glycogen synthase kinase 3-alpha (GSK3A) is a multifunctional protein serine kinase, homologous to Drosophila """shaggy""" (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and transcription factors.It also plays a role in the WNT  and PI3K signaling pathways (see review by .